Beta-lactamase NDM-1 · SINGLE PROTEIN · Escherichia coli
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt E5KIY2. Use UniProt E5KIY2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt E5KIY2 as the stable identity anchor, then attach disease evidence before program review.
Beta-lactamase
Review this target as Beta-lactamase NDM-1, mapped to UniProt E5KIY2. ChEMBL maps the protein component as Beta-lactamase. Sequence length is 270 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Beta-lactamase NDM-1 as ChEMBL target CHEMBL4295540, mapped to UniProt E5KIY2. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Beta-lactamase NDM-1 is the right protein anchor across sources, using UniProt E5KIY2 as the stable mapping.
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| Preferred Name | Beta-lactamase NDM-1 |
| Target Type | SINGLE PROTEIN |
| Organism | Escherichia coli |
| UniProt | E5KIY2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Beta-lactamase |
| UniProt Accession | E5KIY2 |
| Component Type | Protein |
| Sequence Length | 270 aa |
Beta-lactamase
Review this target as Beta-lactamase NDM-1, mapped to UniProt E5KIY2. ChEMBL maps the protein component as Beta-lactamase. Sequence length is 270 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2005280 | 6.96 | IC50 | 109.5 | Preclinical |
| CHEMBL197194 | 6.47 | Kd | 337.0 | Clinical |
| CHEMBL2005280 | 5.29 | Ki | 5110.0 | Preclinical |
| CHEMBL4212352 | 5.25 | IC50 | 5624.0 | Preclinical |
| CHEMBL4212352 | 5.25 | Ki | 5630.0 | Preclinical |
| CHEMBL1560 | 5.16 | IC50 | 7000.0 | Approved |
| CHEMBL5396807 | 5.0 | IC50 | 10000.0 | Preclinical |
| CHEMBL197194 | 4.86 | IC50 | 13800.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 46 | 5 | 5.6 |
| assay format | 6 | 1 | 4.9 |