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Target Snapshot

CHEMBL4295560 Target Snapshot

Phospho-N-acetylmuramoyl-pentapeptide-transferase · SINGLE PROTEIN · Aquifex aeolicus (strain VF5)

26Compounds
3Assays
0Approved Drugs
26.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O66465. Use UniProt O66465 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O66465 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Phospho-N-acetylmuramoyl-pentapeptide-transferase as ChEMBL target CHEMBL4295560, mapped to UniProt O66465. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Phospho-N-acetylmuramoyl-pentapeptide-transferase
SINGLE PROTEIN · Aquifex aeolicus (strain VF5)
As of 2026-09-14
ChEMBL target ID
CHEMBL4295560
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O66465
Phospho-N-acetylmuramoyl-pentapeptide-transferase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Phospho-N-acetylmuramoyl-pentapeptide-transferase is the right protein anchor across sources, using UniProt O66465 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPhospho-N-acetylmuramoyl-pentapeptide-transferase
UniProt AccessionO66465
Component TypeProtein
Sequence Length359 aa

Phospho-N-acetylmuramoyl-pentapeptide-transferase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Phospho-N-acetylmuramoyl-pentapeptide-transferase, mapped to UniProt O66465. Sequence length is 359 aa.

Mapped IDO66465
Review namePhospho-N-acetylmuramoyl-pentapeptide-transferase
OrganismAquifex aeolicus (strain VF5)
Assay Mix

Activity Type Distribution

IC5026.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4279378 9.49 IC50 0.32 Preclinical
CHEMBL4286766 9.46 IC50 0.35 Preclinical
CHEMBL4592367 4.82 IC50 15000.0 Preclinical
CHEMBL4441639 4.7 IC50 20000.0 Preclinical
CHEMBL4521972 4.7 IC50 20000.0 Preclinical
CHEMBL4452848 4.6 IC50 25000.0 Preclinical
CHEMBL4524781 4.6 IC50 25000.0 Preclinical
CHEMBL4565456 4.6 IC50 25000.0 Preclinical
CHEMBL4577355 4.52 IC50 30000.0 Preclinical
CHEMBL4555507 4.46 IC50 35000.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
2
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

3
Total Assays
25
Tested Compounds
1
Assay Types
Binding — 3 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 22 4.4
assay format 1 3 9.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine