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Target Snapshot

CHEMBL4295578 Target Snapshot

Proteasome subunit beta type-1 · SINGLE PROTEIN · Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)

7Compounds
1Assays
0Approved Drugs
7.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P38624. Use UniProt P38624 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P38624 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Proteasome subunit beta type-1 as ChEMBL target CHEMBL4295578, mapped to UniProt P38624. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Proteasome subunit beta type-1
SINGLE PROTEIN · Saccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
As of 2026-09-14
ChEMBL target ID
CHEMBL4295578
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P38624
Proteasome subunit beta type-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Proteasome subunit beta type-1 is the right protein anchor across sources, using UniProt P38624 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProteasome subunit beta type-1
UniProt AccessionP38624
Component TypeProtein
Sequence Length215 aa

Proteasome subunit beta type-1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Proteasome subunit beta type-1, mapped to UniProt P38624. Sequence length is 215 aa.

Mapped IDP38624
Review nameProteasome subunit beta type-1
OrganismSaccharomyces cerevisiae (strain ATCC 204508 / S288c) (Baker's yeast)
Assay Mix

Activity Type Distribution

IC507.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4285979 6.11 IC50 779.0 Preclinical
CHEMBL4292798 5.86 IC50 1383.0 Preclinical
CHEMBL4293877 5.61 IC50 2482.0 Preclinical
CHEMBL4286154 5.38 IC50 4178.0 Preclinical
CHEMBL4282765 4.99 IC50 10150.0 Preclinical
CHEMBL4290778 4.75 IC50 17750.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
2
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
6
Tested Compounds
1
Assay Types
Binding — 1 assays, 6 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 6 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine