1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic · SINGLE PROTEIN · Plasmodium falciparum (isolate 3D7)
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As of 2026-09-141-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic shows late clinical disease relevance led by malaria. 1 more disease program remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q8IKG4. Start with malaria, then reuse UniProt Q8IKG4 as the stable protein anchor across project notes and exports.
Start with malaria, then reuse UniProt Q8IKG4 as the stable protein anchor across project notes and exports.
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic shows late clinical disease relevance led by malaria. 1 more disease program remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with malaria because it currently carries late clinical support. Linked drugs include FOSMIDOMYCIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxy1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
Review this target as 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, mapped to UniProt Q8IKG4. Sequence length is 488 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic as ChEMBL target CHEMBL4295619, mapped to UniProt Q8IKG4. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic is the right protein anchor across sources, using UniProt Q8IKG4 as the stable mapping.
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| Preferred Name | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
| Target Type | SINGLE PROTEIN |
| Organism | Plasmodium falciparum (isolate 3D7) |
| UniProt | Q8IKG4 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic |
| UniProt Accession | Q8IKG4 |
| Component Type | Protein |
| Sequence Length | 488 aa |
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic
Review this target as 1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic, mapped to UniProt Q8IKG4. Sequence length is 488 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
1-deoxy-D-xylulose 5-phosphate reductoisomerase, apicoplastic shows late clinical disease relevance led by malaria. 1 more disease program remain visible in the same review block.
Start review with malaria because it currently carries late clinical support. Linked drugs include FOSMIDOMYCIN. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4567904 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL4590343 | 7.89 | IC50 | 13.0 | Preclinical |
| CHEMBL2164257 | 7.7 | Ki | 20.0 | Preclinical |
| CHEMBL4592986 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL205338 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL1922604 | 7.64 | IC50 | 23.0 | Preclinical |
| CHEMBL4544750 | 7.62 | IC50 | 24.0 | Preclinical |
| CHEMBL4474216 | 7.54 | IC50 | 29.0 | Preclinical |
| CHEMBL4447571 | 7.5 | IC50 | 32.0 | Preclinical |
| CHEMBL2164257 | 7.47 | IC50 | 34.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 9 | 10 | 6.7 |
| assay format | 3 | 15 | 6.5 |
| cell-based format | 3 | 7 | 5.5 |