Nonstructural protein 5 · SINGLE PROTEIN · Dengue virus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt V5TFZ2. Use UniProt V5TFZ2 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt V5TFZ2 as the stable identity anchor, then attach disease evidence before program review.
Genome polyprotein
Review this target as Nonstructural protein 5, mapped to UniProt V5TFZ2. ChEMBL maps the protein component as Genome polyprotein. Sequence length is 900 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Nonstructural protein 5 as ChEMBL target CHEMBL4295629, mapped to UniProt V5TFZ2. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Nonstructural protein 5 |
| Target Type | SINGLE PROTEIN |
| Organism | Dengue virus |
| UniProt | V5TFZ2 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Genome polyprotein |
| UniProt Accession | V5TFZ2 |
| Component Type | Protein |
| Sequence Length | 900 aa |
Genome polyprotein
Review this target as Nonstructural protein 5, mapped to UniProt V5TFZ2. ChEMBL maps the protein component as Genome polyprotein. Sequence length is 900 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4449109 | 7.89 | EC50 | 13.0 | Preclinical |
| CHEMBL4282493 | 7.8 | IC50 | 16.0 | Preclinical |
| CHEMBL1214186 | 7.39 | IC50 | 41.0 | Clinical |
| CHEMBL450522 | 6.8 | IC50 | 160.0 | Preclinical |
| CHEMBL1230055 | 6.77 | Ki | 170.0 | Preclinical |
| CHEMBL4288319 | 6.6 | Ki | 251.9 | Preclinical |
| CHEMBL291426 | 6.58 | IC50 | 260.0 | Preclinical |
| CHEMBL63677 | 6.48 | IC50 | 330.0 | Preclinical |
| CHEMBL4126343 | 6.47 | IC50 | 340.0 | Preclinical |
| CHEMBL3417270 | 6.44 | IC50 | 360.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 34 | 74 | 5.5 |
| assay format | 3 | 0 | — |
| cell-based format | 2 | 2 | 7.3 |