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Target Snapshot

CHEMBL4295695 Target Snapshot

Metallo-beta-lactamase type 2 · SINGLE PROTEIN · Bacillus cereus

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65Compounds
3Assays
0Approved Drugs
59.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P04190. Use UniProt P04190 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P04190 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Metallo-beta-lactamase type 2 as ChEMBL target CHEMBL4295695, mapped to UniProt P04190. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Metallo-beta-lactamase type 2
SINGLE PROTEIN · Bacillus cereus
As of 2026-09-14
ChEMBL target ID
CHEMBL4295695
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P04190
Metallo-beta-lactamase type 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Choose the first block or source based on the question you are trying to answer.

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Metallo-beta-lactamase type 2 is the right protein anchor across sources, using UniProt P04190 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMetallo-beta-lactamase type 2
Target TypeSINGLE PROTEIN
OrganismBacillus cereus
UniProtP04190
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMetallo-beta-lactamase type 2
UniProt AccessionP04190
Component TypeProtein
Sequence Length257 aa

Metallo-beta-lactamase type 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Metallo-beta-lactamase type 2, mapped to UniProt P04190. Sequence length is 257 aa.

Mapped IDP04190
Review nameMetallo-beta-lactamase type 2
OrganismBacillus cereus
Assay Mix

Activity Type Distribution

IC5059.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4127821 7.22 IC50 60.0 Preclinical
CHEMBL4127736 7.16 IC50 70.0 Preclinical
CHEMBL3792857 7.1 IC50 80.0 Preclinical
CHEMBL3234727 7.0 IC50 100.0 Preclinical
CHEMBL4125829 7.0 IC50 100.0 Preclinical
CHEMBL1559342 6.7 IC50 200.0 Preclinical
CHEMBL4128221 6.7 IC50 200.0 Preclinical
CHEMBL4129411 6.7 IC50 200.0 Preclinical
CHEMBL4068716 6.52 IC50 300.0 Preclinical
CHEMBL4126465 6.52 IC50 300.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
7
5.5
5
6.0
5
6.5
5
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

3
Total Assays
39
Tested Compounds
1
Assay Types
Binding — 3 assays, 39 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 39 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine