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Target Snapshot

CHEMBL4295736 Target Snapshot

Peptidyl-prolyl cis-trans isomerase FKBP1A · SINGLE PROTEIN · Mus musculus

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19Compounds
1Assays
1Approved Drugs
19.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P26883. Use UniProt P26883 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P26883 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Peptidyl-prolyl cis-trans isomerase FKBP1A as ChEMBL target CHEMBL4295736, mapped to UniProt P26883. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Peptidyl-prolyl cis-trans isomerase FKBP1A
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4295736
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P26883
Peptidyl-prolyl cis-trans isomerase FKBP1A
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Peptidyl-prolyl cis-trans isomerase FKBP1A is the right protein anchor across sources, using UniProt P26883 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NamePeptidyl-prolyl cis-trans isomerase FKBP1A
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtP26883
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPeptidyl-prolyl cis-trans isomerase FKBP1A
UniProt AccessionP26883
Component TypeProtein
Sequence Length108 aa

Peptidyl-prolyl cis-trans isomerase FKBP1A

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Peptidyl-prolyl cis-trans isomerase FKBP1A, mapped to UniProt P26883. Sequence length is 108 aa.

Mapped IDP26883
Review namePeptidyl-prolyl cis-trans isomerase FKBP1A
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5019.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL413 9.0 IC50 1.0 Approved
CHEMBL4287849 8.7 IC50 2.0 Preclinical
CHEMBL4280369 8.4 IC50 4.0 Preclinical
CHEMBL4291011 8.4 IC50 4.0 Preclinical
CHEMBL4279511 8.22 IC50 6.0 Preclinical
CHEMBL4287588 8.0 IC50 10.0 Preclinical
CHEMBL4291252 7.96 IC50 11.0 Preclinical
CHEMBL4281041 7.7 IC50 20.0 Preclinical
CHEMBL4283415 7.7 IC50 20.0 Preclinical
CHEMBL4276944 7.52 IC50 30.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
1
5.5
1
6.0
1
6.5
3
7.0
4
7.5
4
8.0
1
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

SIROLIMUS
CHEMBL413
Approved 1999
Properties Compare Identifier
Assay Landscape

Assay Landscape

1
Total Assays
16
Tested Compounds
1
Assay Types
Binding — 1 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 16 7.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine