Serine hydroxymethyltransferase, mitochondrial · SINGLE PROTEIN · Homo sapiens
This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.
Move to another high-traffic target or paste a specific ChEMBL target ID.
Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P34897. Use UniProt P34897 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P34897 as the stable identity anchor, then attach disease evidence before program review.
Serine hydroxymethyltransferase, mitochondrial
Review this target as Serine hydroxymethyltransferase, mitochondrial, mapped to UniProt P34897. Sequence length is 504 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Serine hydroxymethyltransferase, mitochondrial as ChEMBL target CHEMBL4295747, mapped to UniProt P34897. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Serine hydroxymethyltransferase, mitochondrial is the right protein anchor across sources, using UniProt P34897 as the stable mapping.
Jump to Protein ContextUse this block first when you need the strongest disease program and evidence level in one place.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Serine hydroxymethyltransferase, mitochondrial |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P34897 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Serine hydroxymethyltransferase, mitochondrial |
| UniProt Accession | P34897 |
| Component Type | Protein |
| Sequence Length | 504 aa |
Serine hydroxymethyltransferase, mitochondrial
Review this target as Serine hydroxymethyltransferase, mitochondrial, mapped to UniProt P34897. Sequence length is 504 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5440815 | 7.8 | Ki | 16.0 | Preclinical |
| CHEMBL5429283 | 7.22 | Ki | 60.0 | Preclinical |
| CHEMBL5438587 | 7.1 | Ki | 80.0 | Preclinical |
| CHEMBL5431881 | 6.47 | Ki | 340.0 | Preclinical |
| CHEMBL5653589 | 6.46 | Kd | 345.44 | Preclinical |
| CHEMBL506 | 6.36 | IC50 | 436.52 | Approved |
| CHEMBL5405010 | 6.35 | Ki | 450.0 | Preclinical |
| CHEMBL5408906 | 6.34 | Ki | 460.0 | Preclinical |
| CHEMBL4530254 | 6.27 | IC50 | 540.0 | Preclinical |
| CHEMBL5427804 | 6.2 | Ki | 630.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 3 | 211 | 5.5 |
| single protein format | 2 | 44 | 4.8 |
| cell-based format | 1 | 0 | — |