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Target Snapshot

CHEMBL4295799 Target Snapshot

Neurogenic locus notch homolog protein 1 · SINGLE PROTEIN · Mus musculus

10Compounds
11Assays
0Approved Drugs
8.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q01705. Use UniProt Q01705 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q01705 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neurogenic locus notch homolog protein 1 as ChEMBL target CHEMBL4295799, mapped to UniProt Q01705. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neurogenic locus notch homolog protein 1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4295799
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q01705
Neurogenic locus notch homolog protein 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neurogenic locus notch homolog protein 1 is the right protein anchor across sources, using UniProt Q01705 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeurogenic locus notch homolog protein 1
UniProt AccessionQ01705
Component TypeProtein
Sequence Length2531 aa

Neurogenic locus notch homolog protein 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Neurogenic locus notch homolog protein 1, mapped to UniProt Q01705. Sequence length is 2531 aa.

Mapped IDQ01705
Review nameNeurogenic locus notch homolog protein 1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase I
Assay Mix

Activity Type Distribution

IC508.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4285883 6.92 IC50 120.0 Preclinical
CHEMBL4292704 5.6 IC50 2500.0 Preclinical
CHEMBL229258 5.57 IC50 2700.0 Preclinical
CHEMBL4282921 5.57 IC50 2700.0 Preclinical
CHEMBL229259 5.38 IC50 4200.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
3
5.5
0
6.0
1
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

11
Total Assays
5
Tested Compounds
1
Assay Types
Binding — 11 assays, 5 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 5 5.8

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine