Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL4295801 Target Snapshot

Protein ENL · SINGLE PROTEIN · Homo sapiens

181Compounds
80Assays
0Approved Drugs
228.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q03111. Use UniProt Q03111 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q03111 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein ENL as ChEMBL target CHEMBL4295801, mapped to UniProt Q03111. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein ENL
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4295801
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q03111
Protein ENL
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein ENL is the right protein anchor across sources, using UniProt Q03111 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein ENL
UniProt AccessionQ03111
Component TypeProtein
Sequence Length559 aa

Protein ENL

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Protein ENL, mapped to UniProt Q03111. Sequence length is 559 aa.

Mapped IDQ03111
Review nameProtein ENL
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC50148.0
KI43.0
KD37.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4210431 8.85 Ki 1.43 Preclinical
CHEMBL5187921 8.47 Ki 3.37 Preclinical
CHEMBL5400413 7.97 IC50 10.7 Preclinical
CHEMBL4552313 7.85 IC50 14.0 Preclinical
CHEMBL5423431 7.84 IC50 14.5 Preclinical
CHEMBL5438748 7.81 IC50 15.4 Preclinical
CHEMBL5397340 7.77 IC50 17.0 Preclinical
CHEMBL5438748 7.77 Kd 17.0 Preclinical
CHEMBL5411777 7.76 IC50 17.2 Preclinical
CHEMBL5404010 7.72 IC50 18.9 Preclinical
Distribution

pChEMBL Value Distribution

25
5.0
27
5.5
33
6.0
47
6.5
31
7.0
19
7.5
1
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

80
Total Assays
147
Tested Compounds
2
Assay Types
Binding — 79 assays, 147 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 46 78 6.4
cell-based format 19 27 7.4
assay format 14 42 5.6
Functional — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 1 7.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine