Dihydroorotate dehydrogenase (fumarate) · SINGLE PROTEIN · Leishmania major
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As of 2026-09-14Protein identity stays anchored to UniProt Q4QEW7. Use UniProt Q4QEW7 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q4QEW7 as the stable identity anchor, then attach disease evidence before program review.
Dihydroorotate dehydrogenase (fumarate)
Review this target as Dihydroorotate dehydrogenase (fumarate), mapped to UniProt Q4QEW7. Sequence length is 320 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydroorotate dehydrogenase (fumarate) as ChEMBL target CHEMBL4295843, mapped to UniProt Q4QEW7. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dihydroorotate dehydrogenase (fumarate) |
| Target Type | SINGLE PROTEIN |
| Organism | Leishmania major |
| UniProt | Q4QEW7 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydroorotate dehydrogenase (fumarate) |
| UniProt Accession | Q4QEW7 |
| Component Type | Protein |
| Sequence Length | 320 aa |
Dihydroorotate dehydrogenase (fumarate)
Review this target as Dihydroorotate dehydrogenase (fumarate), mapped to UniProt Q4QEW7. Sequence length is 320 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4279879 | 4.6 | IC50 | 25118.86 | Preclinical |
| CHEMBL164 | 4.52 | IC50 | 29910.0 | Preclinical |
| CHEMBL4278902 | 4.51 | IC50 | 30900.0 | Preclinical |
| CHEMBL489140 | 4.5 | IC50 | 31500.0 | Preclinical |
| CHEMBL177126 | 4.13 | IC50 | 73200.0 | Preclinical |
| CHEMBL226034 | 4.03 | IC50 | 93700.0 | Preclinical |
| CHEMBL311498 | 4.01 | IC50 | 98300.0 | Approved |
| CHEMBL487017 | 4.0 | IC50 | 100000.0 | Preclinical |
| CHEMBL516873 | 4.0 | IC50 | 100000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 0 | — |
| cell-based format | 3 | 56 | 4.3 |