Review anchor
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
Evidence Snapshot
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
CHEMBL4295913
SINGLE PROTEIN
Rattus norvegicus
Identity Layer
Cross-source identity
Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 as ChEMBL target CHEMBL4295913, mapped to UniProt Q924C3. Disease framing currently uses the Open Targets-ready proxy contract.
ChEMBL target ID
CHEMBL4295913
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine
As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q924C3
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
UniProt accession via ChEMBL component mapping
As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy
As of 2026-09-14
www.ebi.ac.uk
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Review-ready Target Rationale
Why Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 matters
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 is reviewed as Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (UniProt Q924C3); the current evidence base includes 0 approved drugs, 7 compounds, and 3 assays, with lead potency reaching pChEMBL 5.7.
Protein context
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 Sequence length is 906 aa.
Review this target as Ectonucleotide pyrophosphatase/phosphodiesterase family member 1, mapped to UniProt Q924C3. Sequence length is 906 aa.
Protein source · UniProt accession via ChEMBL component mapping
UniProt Q924C3
Protein
Disease context
Disease signal
Disease relevance is not yet populated for this evidence card.
This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
ChEMBL target recordActivity base
Portfolio and assay base
ChEMBL currently tracks 0 approved drugs, 7 compounds, and 3 assays for this target. The dominant activity type is KI. CHEMBL132722 is the current potency anchor at pChEMBL 5.7.
Use CHEMBL132722 as the tractability anchor when discussing potency (pChEMBL 5.7).
Activity source · ChEMBL 36 via Core Engine
pChEMBL 5.7
Source Guidance
Start with the right source
Pick the first block or linked source that matches the review question in front of you.
Need the shortest review narrative first?
Review-ready Target Rationale
One-page rationale with as-of-date and attribution
Start with the review rationale when you need to explain why Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 matters before drilling into raw source blocks.
Jump to Review RationaleNeed stable protein naming or accession mapping?
UniProt Target Context
UniProt accession via ChEMBL component mapping
Go back to the target snapshot when you need the naming and mapping contract behind UniProt Q924C3, not just the summarized rationale.
Open Protein ContextNeed disease fit or evidence level for program framing?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy
Use the target snapshot disease block when you need the disease program and supporting signals, not only the card summary.
Open Disease ContextSnapshot State
No project snapshot selected. Export uses the live evidence card state.
7
Total Compounds
3
Total Assays
0
Approved Drugs
IC50: 2.0, KI: 5.0
Activity Types
pChEMBL Activity Distribution
Top 5 Inhibitors (by pChEMBL)
| Structure | Compound | pChEMBL | Type | Phase |
|---|---|---|---|---|
|
|
No preferred name
CHEMBL132722
|
5.7 | Ki | — |
|
|
No preferred name
CHEMBL583969
|
5.0 | Ki | — |
|
|
No preferred name
CHEMBL4285222
|
5.0 | Ki | — |
|
|
No preferred name
CHEMBL69234
|
4.9 | IC50 | — |
|
|
No preferred name
CHEMBL2407634
|
4.7 | Ki | — |
Source Header