Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 · PROTEIN COMPLEX · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P30191. Use UniProt P30191 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P30191 as the stable identity anchor, then attach disease evidence before program review.
Gamma-aminobutyric acid receptor subunit alpha-6
Review this target as Gamma-aminobutyric acid receptor subunit alpha-6/beta-3, mapped to UniProt P30191. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-6. Sequence length is 453 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 as ChEMBL target CHEMBL4296052, mapped to UniProt P30191. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Gamma-aminobutyric acid receptor subunit alpha-6/beta-3 |
| Target Type | PROTEIN COMPLEX |
| Organism | Rattus norvegicus |
| UniProt | P30191 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Gamma-aminobutyric acid receptor subunit alpha-6 |
| UniProt Accession | P30191 |
| Component Type | Protein |
| Sequence Length | 453 aa |
Gamma-aminobutyric acid receptor subunit alpha-6
Review this target as Gamma-aminobutyric acid receptor subunit alpha-6/beta-3, mapped to UniProt P30191. ChEMBL maps the protein component as Gamma-aminobutyric acid receptor subunit alpha-6. Sequence length is 453 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4213357 | 6.77 | EC50 | 170.0 | Preclinical |
| CHEMBL4213357 | 6.1 | IC50 | 790.0 | Preclinical |
| CHEMBL4213793 | 5.89 | IC50 | 1290.0 | Preclinical |
| CHEMBL4212818 | 5.61 | EC50 | 2440.0 | Preclinical |
| CHEMBL4204097 | 5.6 | IC50 | 2500.0 | Preclinical |
| CHEMBL4216298 | 5.51 | IC50 | 3060.0 | Preclinical |
| CHEMBL4208971 | 5.39 | IC50 | 4070.0 | Preclinical |
| CHEMBL4208437 | 4.8 | IC50 | 16000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 11 | 7 | 5.7 |