Lysine-specific histone demethylase 1A/REST corepressor · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O60341. Use UniProt O60341 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O60341 as the stable identity anchor, then attach disease evidence before program review.
Lysine-specific histone demethylase 1A
Review this target as Lysine-specific histone demethylase 1A/REST corepressor, mapped to UniProt O60341. ChEMBL maps the protein component as Lysine-specific histone demethylase 1A. Sequence length is 852 aa.
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This review treats Lysine-specific histone demethylase 1A/REST corepressor as ChEMBL target CHEMBL4296114, mapped to UniProt O60341. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Lysine-specific histone demethylase 1A/REST corepressor |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | O60341 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Lysine-specific histone demethylase 1A |
| UniProt Accession | O60341 |
| Component Type | Protein |
| Sequence Length | 852 aa |
Lysine-specific histone demethylase 1A
Review this target as Lysine-specific histone demethylase 1A/REST corepressor, mapped to UniProt O60341. ChEMBL maps the protein component as Lysine-specific histone demethylase 1A. Sequence length is 852 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4228572 | 5.62 | IC50 | 2400.0 | Preclinical |
| CHEMBL4228166 | 5.42 | IC50 | 3850.0 | Preclinical |
| CHEMBL3989843 | 4.05 | IC50 | 89080.0 | Approved |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 3 | 5.0 |