von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-15Protein identity stays anchored to UniProt Q16665. Use UniProt Q16665 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q16665 as the stable identity anchor, then attach disease evidence before program review.
Hypoxia-inducible factor 1-alpha
Review this target as von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A, mapped to UniProt Q16665. ChEMBL maps the protein component as Hypoxia-inducible factor 1-alpha. Sequence length is 826 aa.
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This review treats von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A as ChEMBL target CHEMBL4296117, mapped to UniProt Q16665. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | Q16665 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hypoxia-inducible factor 1-alpha |
| UniProt Accession | Q16665 |
| Component Type | Protein |
| Sequence Length | 826 aa |
Hypoxia-inducible factor 1-alpha
Review this target as von Hippel-Lindau disease tumor suppressor/Elongin-C/Elongin-B/HIF1A, mapped to UniProt Q16665. ChEMBL maps the protein component as Hypoxia-inducible factor 1-alpha. Sequence length is 826 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3344081 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL4226250 | 6.1 | IC50 | 800.0 | Preclinical |
| CHEMBL4227907 | 5.31 | IC50 | 4900.0 | Preclinical |
| CHEMBL4225691 | 5.26 | IC50 | 5500.0 | Preclinical |
| CHEMBL4227623 | 5.0 | IC50 | 9900.0 | Preclinical |
| CHEMBL4226773 | 4.8 | IC50 | 16000.0 | Preclinical |
| CHEMBL4226398 | 4.6 | IC50 | 25000.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 0 | — |
| protein complex format | 1 | 7 | 5.3 |