Protein cereblon/BCR/ABL · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P00519. Use UniProt P00519 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00519 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein kinase ABL1
Review this target as Protein cereblon/BCR/ABL, mapped to UniProt P00519. ChEMBL maps the protein component as Tyrosine-protein kinase ABL1. Sequence length is 1130 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Protein cereblon/BCR/ABL as ChEMBL target CHEMBL4296137, mapped to UniProt P00519. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Protein cereblon/BCR/ABL is the right protein anchor across sources, using UniProt P00519 as the stable mapping.
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| Preferred Name | Protein cereblon/BCR/ABL |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | P00519 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein kinase ABL1 |
| UniProt Accession | P00519 |
| Component Type | Protein |
| Sequence Length | 1130 aa |
Tyrosine-protein kinase ABL1
Review this target as Protein cereblon/BCR/ABL, mapped to UniProt P00519. ChEMBL maps the protein component as Tyrosine-protein kinase ABL1. Sequence length is 1130 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4748640 | 9.96 | Kd | 0.11 | Preclinical |
| CHEMBL4742867 | 9.89 | Kd | 0.13 | Preclinical |
| CHEMBL4747034 | 9.64 | Kd | 0.23 | Preclinical |
| CHEMBL4642168 | 9.49 | Kd | 0.32 | Preclinical |
| CHEMBL4742759 | 9.26 | Kd | 0.55 | Preclinical |
| CHEMBL4642168 | 8.36 | EC50 | 4.4 | Preclinical |
| CHEMBL4208229 | 8.24 | EC50 | 5.8 | Approved |
| CHEMBL1171837 | 7.97 | EC50 | 10.6 | Approved |
| CHEMBL4640401 | 7.54 | EC50 | 28.5 | Preclinical |
| CHEMBL4649252 | 6.35 | EC50 | 450.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 65 | 12 | 6.7 |
| protein format | 2 | 5 | 9.5 |