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Target Snapshot

CHEMBL4296298 Target Snapshot

Genome polyprotein · SINGLE PROTEIN · Hepacivirus C

32Compounds
8Assays
1Approved Drugs
66.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt K7XJL6. Use UniProt K7XJL6 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt K7XJL6 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Genome polyprotein as ChEMBL target CHEMBL4296298, mapped to UniProt K7XJL6. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Genome polyprotein
SINGLE PROTEIN · Hepacivirus C
As of 2026-09-14
ChEMBL target ID
CHEMBL4296298
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
K7XJL6
Genome polyprotein
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Genome polyprotein is the right protein anchor across sources, using UniProt K7XJL6 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGenome polyprotein
UniProt AccessionK7XJL6
Component TypeProtein
Sequence Length695 aa

Genome polyprotein

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Genome polyprotein, mapped to UniProt K7XJL6. Sequence length is 695 aa.

Mapped IDK7XJL6
Review nameGenome polyprotein
OrganismHepacivirus C
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

KI66.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2063089 10.3 Ki 0.05 Preclinical
CHEMBL2063088 10.22 Ki 0.06 Preclinical
CHEMBL2063090 9.85 Ki 0.14 Approved
CHEMBL2203889 9.7 Ki 0.2 Preclinical
CHEMBL2203884 9.4 Ki 0.4 Preclinical
CHEMBL2203879 9.15 Ki 0.7 Preclinical
CHEMBL2203888 9.15 Ki 0.7 Preclinical
CHEMBL2203874 9.1 Ki 0.8 Preclinical
CHEMBL2203892 8.92 Ki 1.2 Preclinical
CHEMBL2203893 8.82 Ki 1.5 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
3
6.0
1
6.5
13
7.0
17
7.5
9
8.0
12
8.5
4
9.0
2
9.5
pChEMBL
Approved Drugs

Approved Drugs

GRAZOPREVIR ANHYDROUS
CHEMBL2063090
Approved 2016
Assay Landscape

Assay Landscape

8
Total Assays
32
Tested Compounds
1
Assay Types
Binding — 8 assays, 32 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 8 32 8.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine