NS3 protease · SINGLE PROTEIN · Hepatitis C virus subtype 1b
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As of 2026-09-14Protein identity stays anchored to UniProt Q0ZMF1. Use UniProt Q0ZMF1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q0ZMF1 as the stable identity anchor, then attach disease evidence before program review.
NS3 protease
Review this target as NS3 protease, mapped to UniProt Q0ZMF1. Sequence length is 181 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats NS3 protease as ChEMBL target CHEMBL4296325, mapped to UniProt Q0ZMF1. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether NS3 protease is the right protein anchor across sources, using UniProt Q0ZMF1 as the stable mapping.
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| Preferred Name | NS3 protease |
| Target Type | SINGLE PROTEIN |
| Organism | Hepatitis C virus subtype 1b |
| UniProt | Q0ZMF1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | NS3 protease |
| UniProt Accession | Q0ZMF1 |
| Component Type | Protein |
| Sequence Length | 181 aa |
NS3 protease
Review this target as NS3 protease, mapped to UniProt Q0ZMF1. Sequence length is 181 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3348818 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3120475 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL3348817 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL3349199 | 10.7 | IC50 | 0.02 | Preclinical |
| CHEMBL3120477 | 10.52 | IC50 | 0.03 | Preclinical |
| CHEMBL3120492 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL3349202 | 10.3 | IC50 | 0.05 | Preclinical |
| CHEMBL3120493 | 10.22 | IC50 | 0.06 | Preclinical |
| CHEMBL2063090 | 10.15 | IC50 | 0.07 | Approved |
| CHEMBL3120488 | 10.0 | IC50 | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 9 | 52 | 8.7 |
| single protein format | 1 | 0 | — |