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Target Snapshot

CHEMBL4296391 Target Snapshot

NCI-H929 · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
374Compounds
225Assays
4Approved Drugs
277.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats NCI-H929 as ChEMBL target CHEMBL4296391. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
NCI-H929
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296391
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether NCI-H929 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameNCI-H929
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNCI-H929
UniProt AccessionN/A

NCI-H929

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as NCI-H929.

Review nameNCI-H929
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
3
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC50238.0
EC5039.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5555963 9.33 EC50 0.47 Preclinical
CHEMBL4754629 9.05 IC50 0.9 Preclinical
CHEMBL5555337 8.96 IC50 1.1 Preclinical
CHEMBL4757943 8.77 IC50 1.7 Preclinical
CHEMBL4788274 8.77 IC50 1.7 Preclinical
CHEMBL4753960 8.51 IC50 3.1 Preclinical
CHEMBL4761750 8.46 IC50 3.5 Preclinical
CHEMBL4776083 8.46 IC50 3.5 Preclinical
CHEMBL4796848 8.43 IC50 3.7 Preclinical
CHEMBL4790907 8.41 IC50 3.9 Preclinical
Distribution

pChEMBL Value Distribution

35
5.0
40
5.5
41
6.0
33
6.5
33
7.0
23
7.5
22
8.0
4
8.5
2
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CARFILZOMIB
CHEMBL451887
Approved 2009
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

225
Total Assays
226
Tested Compounds
1
Assay Types
Functional — 225 assays, 226 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 218 226 6.5
organism-based format 7 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine