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Target Snapshot

CHEMBL4296403 Target Snapshot

BEAS-2B · CELL-LINE · Homo sapiens

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765Compounds
168Assays
12Approved Drugs
488.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats BEAS-2B as ChEMBL target CHEMBL4296403. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
BEAS-2B
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296403
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether BEAS-2B still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBEAS-2B
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBEAS-2B
UniProt AccessionN/A

BEAS-2B

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as BEAS-2B.

Review nameBEAS-2B
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

12
Approved
3
Phase III
4
Phase II
Assay Mix

Activity Type Distribution

IC50458.0
EC5030.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL428647 8.15 IC50 7.0 Approved
CHEMBL107 7.8 IC50 16.0 Approved
CHEMBL398726 7.7 EC50 20.0 Preclinical
CHEMBL888 7.43 IC50 37.0 Approved
CHEMBL252370 7.18 IC50 66.0 Preclinical
CHEMBL4448823 7.04 EC50 91.0 Preclinical
CHEMBL4444727 6.73 EC50 185.0 Preclinical
CHEMBL4859030 6.5 IC50 320.0 Preclinical
CHEMBL4861795 6.39 IC50 410.0 Preclinical
CHEMBL301982 6.34 IC50 454.0 Preclinical
Distribution

pChEMBL Value Distribution

63
5.0
16
5.5
15
6.0
2
6.5
3
7.0
2
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
DACTINOMYCIN
CHEMBL1554
Approved 1964
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

168
Total Assays
117
Tested Compounds
3
Assay Types
Toxicity — 79 assays, 117 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 79 117 4.7
ADME — 53 assays, 115 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 53 115 5.0
Functional — 36 assays, 47 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 36 47 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine