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Target Snapshot

CHEMBL4296405 Target Snapshot

CCD-18Co · CELL-LINE · Homo sapiens

361Compounds
30Assays
3Approved Drugs
348.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats CCD-18Co as ChEMBL target CHEMBL4296405. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
CCD-18Co
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296405
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether CCD-18Co still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCCD-18Co
UniProt AccessionN/A

CCD-18Co

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as CCD-18Co.

Review nameCCD-18Co
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC50348.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4581557 7.39 IC50 40.6 Preclinical
CHEMBL5632064 7.19 IC50 64.1 Preclinical
CHEMBL4752322 7.0 IC50 100.0 Preclinical
CHEMBL6067727 6.92 IC50 118.8 Preclinical
CHEMBL4467135 6.72 IC50 190.0 Preclinical
CHEMBL5173807 6.72 IC50 190.0 Preclinical
CHEMBL5632266 6.6 IC50 250.6 Preclinical
CHEMBL5633595 6.59 IC50 256.0 Preclinical
CHEMBL53463 6.57 IC50 269.0 Approved
CHEMBL4526470 6.48 IC50 330.0 Preclinical
Distribution

pChEMBL Value Distribution

157
5.0
91
5.5
29
6.0
6
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

DOXORUBICIN
CHEMBL53463
Approved 1974
Assay Landscape

Assay Landscape

30
Total Assays
297
Tested Compounds
3
Assay Types
ADME — 22 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 22 20 5.2
Toxicity — 5 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 5 13 6.4
Functional — 3 assays, 297 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 297 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine