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Target Snapshot

CHEMBL4296410 Target Snapshot

EA.hy 926 · CELL-LINE · Homo sapiens

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381Compounds
144Assays
5Approved Drugs
303.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats EA.hy 926 as ChEMBL target CHEMBL4296410. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
EA.hy 926
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4296410
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether EA.hy 926 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameEA.hy 926
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelEA.hy 926
UniProt AccessionN/A

EA.hy 926

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as EA.hy 926.

Review nameEA.hy 926
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

5
Approved
6
Phase III
Assay Mix

Activity Type Distribution

IC50296.0
EC507.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4475290 8.37 IC50 4.3 Preclinical
CHEMBL5184353 8.21 IC50 6.2 Preclinical
CHEMBL67 8.0 IC50 10.0 Preclinical
CHEMBL5176963 7.92 IC50 11.9 Preclinical
CHEMBL5198083 7.8 IC50 15.7 Preclinical
CHEMBL4473535 7.8 IC50 15.9 Preclinical
CHEMBL5188413 7.77 IC50 17.1 Preclinical
CHEMBL5270399 7.75 IC50 18.0 Preclinical
CHEMBL4469871 7.75 IC50 17.9 Preclinical
CHEMBL228363 7.7 IC50 19.9 Preclinical
Distribution

pChEMBL Value Distribution

39
5.0
27
5.5
13
6.0
9
6.5
15
7.0
12
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CERITINIB
CHEMBL2403108
Approved 2014
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
Assay Landscape

Assay Landscape

144
Total Assays
172
Tested Compounds
3
Assay Types
Functional — 128 assays, 172 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 128 172 5.5
ADME — 8 assays, 36 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 36 4.6
Toxicity — 8 assays, 29 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 29 5.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine