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Target Snapshot

CHEMBL4296414 Target Snapshot

FL5.12 · CELL-LINE · Mus musculus

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86Compounds
30Assays
1Approved Drugs
72.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats FL5.12 as ChEMBL target CHEMBL4296414. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
FL5.12
CELL-LINE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4296414
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether FL5.12 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameFL5.12
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelFL5.12
UniProt AccessionN/A

FL5.12

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as FL5.12.

Review nameFL5.12
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC5061.0
EC5011.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL376409 6.92 EC50 120.0 Preclinical
CHEMBL376410 6.92 EC50 120.0 Preclinical
CHEMBL376408 6.66 EC50 220.0 Preclinical
CHEMBL384218 6.16 EC50 700.0 Preclinical
CHEMBL217960 6.15 EC50 710.0 Preclinical
CHEMBL322333 6.1 IC50 800.0 Preclinical
CHEMBL374309 5.92 EC50 1200.0 Preclinical
CHEMBL4467146 5.92 IC50 1200.0 Preclinical
CHEMBL4549134 5.85 IC50 1400.0 Preclinical
CHEMBL4439872 5.77 IC50 1700.0 Preclinical
Distribution

pChEMBL Value Distribution

16
5.0
29
5.5
3
6.0
3
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

30
Total Assays
70
Tested Compounds
1
Assay Types
Functional — 30 assays, 70 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 22 59 5.3
assay format 8 11 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine