Skip to main content
Free research Free research Free target review with research home and workspace preview
Quick search ChEMBL 36
Loading Target Snapshot...
Querying ChEMBL database. This may take a few seconds.
Target Snapshot

CHEMBL4296421 Target Snapshot

HCC78 · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
217Compounds
47Assays
4Approved Drugs
234.0Activities
Free Research Context

Research home keeps recent targets

This target will appear in recent viewed items on this browser. Use the demo workspace to preview watch rules and decision queues.

Research home Demo workspace
Navigation

Switch target

Move to another high-traffic target or paste a specific ChEMBL target ID.

Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HCC78 as ChEMBL target CHEMBL4296421. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HCC78
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4296421
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HCC78 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

Open Review-ready Card
Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHCC78
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHCC78
UniProt AccessionN/A

HCC78

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as HCC78.

Review nameHCC78
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC50234.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5712062 9.0 IC50 1.0 Preclinical
CHEMBL58 7.86 IC50 13.83 Approved
CHEMBL1230609 7.72 IC50 19.0 Clinical
CHEMBL601719 7.68 IC50 21.0 Approved
CHEMBL4470529 7.54 IC50 29.0 Preclinical
CHEMBL4281394 7.46 IC50 35.0 Preclinical
CHEMBL2403108 7.41 IC50 39.0 Approved
CHEMBL4174347 7.4 IC50 40.0 Preclinical
CHEMBL4562805 7.39 IC50 41.0 Preclinical
CHEMBL4277936 7.37 IC50 43.0 Preclinical
Distribution

pChEMBL Value Distribution

11
5.0
10
5.5
64
6.0
44
6.5
33
7.0
5
7.5
0
8.0
1
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LORLATINIB
CHEMBL3286830
Approved 2018
Properties Compare Identifier
CERITINIB
CHEMBL2403108
Approved 2014
Properties Compare Identifier
CRIZOTINIB
CHEMBL601719
Approved 2011
Properties Compare Identifier
MITOXANTRONE
CHEMBL58
Approved 1987
Properties Compare Identifier
Assay Landscape

Assay Landscape

47
Total Assays
193
Tested Compounds
1
Assay Types
Functional — 47 assays, 193 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 47 193 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine