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Target Snapshot

CHEMBL4296436 Target Snapshot

HeLa S3 · CELL-LINE · Homo sapiens

438Compounds
112Assays
4Approved Drugs
337.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats HeLa S3 as ChEMBL target CHEMBL4296436. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
HeLa S3
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296436
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether HeLa S3 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHeLa S3
UniProt AccessionN/A

HeLa S3

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as HeLa S3.

Review nameHeLa S3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

4
Approved
1
Phase III
1
Phase II
Assay Mix

Activity Type Distribution

IC50335.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL412190 11.0 IC50 0.01 Preclinical
CHEMBL4212584 11.0 IC50 0.01 Preclinical
CHEMBL102195 10.54 IC50 0.029 Preclinical
CHEMBL317437 10.19 IC50 0.065 Preclinical
CHEMBL4754742 10.02 IC50 0.096 Preclinical
CHEMBL6067712 9.4 IC50 0.4 Preclinical
CHEMBL4205725 9.27 IC50 0.54 Preclinical
CHEMBL4211650 9.12 IC50 0.76 Preclinical
CHEMBL4215435 8.92 IC50 1.2 Preclinical
CHEMBL4218622 8.92 IC50 1.2 Preclinical
Distribution

pChEMBL Value Distribution

56
5.0
23
5.5
24
6.0
7
6.5
10
7.0
8
7.5
0
8.0
5
8.5
3
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PACLITAXEL
CHEMBL428647
Approved 1992
ETOPOSIDE
CHEMBL44657
Approved 1983
MITOMYCIN
CHEMBL105
Approved 1981
DOXORUBICIN
CHEMBL53463
Approved 1974
Assay Landscape

Assay Landscape

112
Total Assays
155
Tested Compounds
3
Assay Types
Functional — 107 assays, 155 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 104 155 6.0
assay format 3 0
ADME — 4 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 3 4.5
Toxicity — 1 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 4 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine