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Target Snapshot

CHEMBL4296437 Target Snapshot

Hep 3B2 · CELL-LINE · Homo sapiens

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1,476Compounds
959Assays
15Approved Drugs
1,327.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Hep 3B2 as ChEMBL target CHEMBL4296437. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Hep 3B2
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296437
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Hep 3B2 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameHep 3B2
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHep 3B2
UniProt AccessionN/A

Hep 3B2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Hep 3B2.

Review nameHep 3B2
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

15
Approved
3
Phase III
8
Phase II
3
Phase I
Assay Mix

Activity Type Distribution

IC501,284.0
EC5043.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4793468 9.22 IC50 0.6 Preclinical
CHEMBL205924 9.0 EC50 1.0 Preclinical
CHEMBL3828009 9.0 IC50 1.0 Preclinical
CHEMBL4439119 9.0 IC50 1.0 Preclinical
CHEMBL4475216 8.96 IC50 1.1 Preclinical
CHEMBL4784440 8.89 IC50 1.3 Preclinical
CHEMBL4764303 8.82 IC50 1.5 Preclinical
CHEMBL4789141 8.82 IC50 1.5 Preclinical
CHEMBL205924 8.75 IC50 1.79 Preclinical
CHEMBL4457168 8.74 IC50 1.8 Preclinical
Distribution

pChEMBL Value Distribution

253
5.0
180
5.5
96
6.0
68
6.5
62
7.0
47
7.5
22
8.0
17
8.5
4
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

INFIGRATINIB
CHEMBL1852688
Approved 2021
Properties Compare Identifier
LENVATINIB
CHEMBL1289601
Approved 2015
Properties Compare Identifier
PONATINIB
CHEMBL1171837
Approved 2012
Properties Compare Identifier
TOPOTECAN
CHEMBL84
Approved 1996
Properties Compare Identifier
CLADRIBINE
CHEMBL1619
Approved 1993
Properties Compare Identifier
PACLITAXEL
CHEMBL428647
Approved 1992
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
COLCHICINE
CHEMBL107
Approved 1961
Properties Compare Identifier
Assay Landscape

Assay Landscape

960
Total Assays
899
Tested Compounds
3
Assay Types
Functional — 933 assays, 899 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 897 899 5.8
organism-based format 36 0 —
ADME — 21 assays, 55 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 21 55 5.1
Toxicity — 6 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine