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Target Snapshot

CHEMBL4296442 Target Snapshot

J774.1 · CELL-LINE · Mus musculus

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244Compounds
35Assays
1Approved Drugs
157.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats J774.1 as ChEMBL target CHEMBL4296442. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
J774.1
CELL-LINE · Mus musculus
As of 2026-09-13
ChEMBL target ID
CHEMBL4296442
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether J774.1 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameJ774.1
Target TypeCELL-LINE
OrganismMus musculus
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelJ774.1
UniProt AccessionN/A

J774.1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as J774.1.

Review nameJ774.1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC50157.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL375009 6.92 IC50 120.0 Preclinical
CHEMBL220552 6.64 IC50 230.0 Preclinical
CHEMBL374052 6.5 IC50 320.0 Preclinical
CHEMBL221243 6.41 IC50 390.0 Preclinical
CHEMBL220744 6.37 IC50 430.0 Preclinical
CHEMBL384590 6.35 IC50 450.0 Preclinical
CHEMBL218282 6.32 IC50 480.0 Preclinical
CHEMBL463732 6.3 IC50 500.0 Preclinical
CHEMBL463733 6.3 IC50 500.0 Preclinical
CHEMBL374053 6.29 IC50 510.0 Preclinical
Distribution

pChEMBL Value Distribution

31
5.0
28
5.5
11
6.0
3
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

35
Total Assays
105
Tested Compounds
3
Assay Types
Functional — 23 assays, 105 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 23 105 5.1
Toxicity — 8 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 0 —
ADME — 4 assays, 37 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 37 5.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine