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Target Snapshot

CHEMBL4296444 Target Snapshot

JJN-3 · CELL-LINE · Homo sapiens

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65Compounds
39Assays
0Approved Drugs
32.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats JJN-3 as ChEMBL target CHEMBL4296444. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
JJN-3
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296444
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether JJN-3 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameJJN-3
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelJJN-3
UniProt AccessionN/A

JJN-3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as JJN-3.

Review nameJJN-3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase II
Assay Mix

Activity Type Distribution

IC5031.0
EC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4216964 7.54 IC50 29.0 Preclinical
CHEMBL4741330 7.21 EC50 61.0 Preclinical
CHEMBL4212714 7.17 IC50 67.0 Preclinical
CHEMBL4218285 7.07 IC50 85.0 Preclinical
CHEMBL4206684 7.04 IC50 91.0 Preclinical
CHEMBL4211057 6.86 IC50 138.0 Preclinical
CHEMBL4202865 6.85 IC50 141.0 Preclinical
CHEMBL4218937 6.62 IC50 240.0 Preclinical
CHEMBL4207209 6.57 IC50 272.0 Preclinical
CHEMBL4214523 6.54 IC50 288.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
2
5.5
2
6.0
6
6.5
4
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

39
Total Assays
24
Tested Compounds
1
Assay Types
Functional — 39 assays, 24 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 38 24 5.9
organism-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine