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Target Snapshot

CHEMBL4296448 Target Snapshot

K562/A02 · CELL-LINE · Homo sapiens

Back to Search Search this target Browse approvals Evidence Card
316Compounds
131Assays
7Approved Drugs
316.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats K562/A02 as ChEMBL target CHEMBL4296448. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
K562/A02
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296448
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether K562/A02 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameK562/A02
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelK562/A02
UniProt AccessionN/A

K562/A02

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as K562/A02.

Review nameK562/A02
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

7
Approved
2
Phase III
Assay Mix

Activity Type Distribution

IC50312.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5408606 8.22 IC50 6.0 Preclinical
CHEMBL5425898 7.68 IC50 21.0 Preclinical
CHEMBL5432534 7.58 IC50 26.0 Preclinical
CHEMBL247473 7.54 IC50 29.0 Preclinical
CHEMBL247473 7.52 EC50 30.3 Preclinical
CHEMBL5432534 7.31 EC50 48.74 Preclinical
CHEMBL4845962 7.0 IC50 100.0 Preclinical
CHEMBL4852246 7.0 IC50 100.0 Preclinical
CHEMBL2012363 6.92 IC50 120.0 Preclinical
CHEMBL2012363 6.91 EC50 122.0 Preclinical
Distribution

pChEMBL Value Distribution

17
5.0
23
5.5
17
6.0
11
6.5
5
7.0
4
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

IMATINIB
CHEMBL941
Approved 2001
Properties Compare Identifier
Assay Landscape

Assay Landscape

131
Total Assays
95
Tested Compounds
3
Assay Types
Functional — 120 assays, 95 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 100 95 5.5
organism-based format 20 0 —
ADME — 9 assays, 29 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 8 29 4.4
organism-based format 1 0 —
Toxicity — 2 assays, 15 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 15 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine