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Target Snapshot

CHEMBL4296449 Target Snapshot

K562/Adr · CELL-LINE · Homo sapiens

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107Compounds
127Assays
8Approved Drugs
86.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats K562/Adr as ChEMBL target CHEMBL4296449. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
K562/Adr
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296449
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether K562/Adr still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameK562/Adr
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelK562/Adr
UniProt AccessionN/A

K562/Adr

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as K562/Adr.

Review nameK562/Adr
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC5086.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3356793 8.59 IC50 2.6 Preclinical
CHEMBL5206531 8.15 IC50 7.1 Preclinical
CHEMBL23474 7.96 IC50 11.0 Preclinical
CHEMBL277216 7.96 IC50 11.0 Preclinical
CHEMBL4846693 7.96 IC50 11.0 Preclinical
CHEMBL4849295 7.96 IC50 11.0 Preclinical
CHEMBL4862841 7.96 IC50 11.0 Preclinical
CHEMBL4866027 7.96 IC50 11.0 Preclinical
CHEMBL4870358 7.96 IC50 11.0 Preclinical
CHEMBL4870773 7.96 IC50 11.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
4
5.5
6
6.0
9
6.5
10
7.0
19
7.5
1
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PODOFILOX
CHEMBL61
Approved 1990
Properties Compare Identifier
ETOPOSIDE
CHEMBL44657
Approved 1983
Properties Compare Identifier
VERAPAMIL
CHEMBL6966
Approved 1981
Properties Compare Identifier
DOXORUBICIN
CHEMBL53463
Approved 1974
Properties Compare Identifier
Assay Landscape

Assay Landscape

127
Total Assays
62
Tested Compounds
3
Assay Types
Functional — 123 assays, 62 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 123 62 6.5
ADME — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 0 —
Toxicity — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 6.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine