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Target Snapshot

CHEMBL4296450 Target Snapshot

K562/VCR · CELL-LINE · Homo sapiens

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19Compounds
39Assays
3Approved Drugs
24.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats K562/VCR as ChEMBL target CHEMBL4296450. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
K562/VCR
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296450
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether K562/VCR still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameK562/VCR
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelK562/VCR
UniProt AccessionN/A

K562/VCR

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as K562/VCR.

Review nameK562/VCR
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Approved
Assay Mix

Activity Type Distribution

IC5024.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4474171 7.52 IC50 30.0 Preclinical
CHEMBL4437037 7.51 IC50 31.0 Preclinical
CHEMBL61 7.3 IC50 50.0 Approved
CHEMBL67 7.24 IC50 57.0 Preclinical
CHEMBL4125872 7.12 IC50 76.0 Preclinical
CHEMBL4850506 7.09 IC50 81.0 Preclinical
CHEMBL4862444 7.09 IC50 81.0 Preclinical
CHEMBL4854840 6.7 IC50 202.0 Preclinical
CHEMBL4866085 6.69 IC50 205.0 Preclinical
CHEMBL1592124 6.53 IC50 297.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
2
5.5
1
6.0
3
6.5
6
7.0
2
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PODOFILOX
CHEMBL61
Approved 1990
Properties Compare Identifier
Assay Landscape

Assay Landscape

39
Total Assays
16
Tested Compounds
1
Assay Types
Functional — 39 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 39 16 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine