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Target Snapshot

CHEMBL4296488 Target Snapshot

PaTu 8988t · CELL-LINE · Homo sapiens

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42Compounds
14Assays
1Approved Drugs
40.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats PaTu 8988t as ChEMBL target CHEMBL4296488. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
PaTu 8988t
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296488
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether PaTu 8988t still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NamePaTu 8988t
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelPaTu 8988t
UniProt AccessionN/A

PaTu 8988t

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as PaTu 8988t.

Review namePaTu 8988t
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase I
Assay Mix

Activity Type Distribution

IC5040.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4764390 9.0 IC50 1.0 Preclinical
CHEMBL4171928 7.62 IC50 24.0 Preclinical
CHEMBL5401853 7.62 IC50 24.0 Preclinical
CHEMBL3774991 7.48 IC50 33.0 Preclinical
CHEMBL5403434 7.43 IC50 37.0 Preclinical
CHEMBL4161330 7.22 IC50 60.0 Preclinical
CHEMBL5266691 7.19 IC50 65.0 Preclinical
CHEMBL3128043 7.14 IC50 73.0 Preclinical
CHEMBL4166855 7.14 IC50 73.0 Preclinical
CHEMBL5420878 7.06 IC50 88.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
5
5.5
10
6.0
12
6.5
7
7.0
2
7.5
0
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

14
Total Assays
26
Tested Compounds
1
Assay Types
Functional — 14 assays, 26 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 14 26 6.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine