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Target Snapshot

CHEMBL4296496 Target Snapshot

SU-DHL-6 · CELL-LINE · Homo sapiens

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290Compounds
101Assays
7Approved Drugs
234.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats SU-DHL-6 as ChEMBL target CHEMBL4296496. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
SU-DHL-6
CELL-LINE · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4296496
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether SU-DHL-6 still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSU-DHL-6
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSU-DHL-6
UniProt AccessionN/A

SU-DHL-6

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as SU-DHL-6.

Review nameSU-DHL-6
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

7
Approved
2
Phase III
4
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50232.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5179238 10.22 IC50 0.06 Preclinical
CHEMBL3039502 9.4 IC50 0.4 Approved
CHEMBL4574593 9.33 IC50 0.47 Preclinical
CHEMBL1336 9.0 IC50 1.0 Approved
CHEMBL3629671 9.0 IC50 1.0 Preclinical
CHEMBL5422160 9.0 IC50 1.0 Preclinical
CHEMBL4297615 8.8 IC50 1.6 Clinical
CHEMBL4794328 8.74 IC50 1.8 Preclinical
CHEMBL4561896 8.68 IC50 2.1 Preclinical
CHEMBL3356793 8.68 IC50 2.1 Preclinical
Distribution

pChEMBL Value Distribution

17
5.0
41
5.5
49
6.0
42
6.5
18
7.0
14
7.5
6
8.0
6
8.5
5
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

LENIOLISIB
CHEMBL3643413
Approved 2023
Properties Compare Identifier
DUVELISIB
CHEMBL3039502
Approved 2018
Properties Compare Identifier
IDELALISIB
CHEMBL2216870
Approved 2014
Properties Compare Identifier
IBRUTINIB
CHEMBL1873475
Approved 2013
Properties Compare Identifier
VORINOSTAT
CHEMBL98
Approved 2006
Properties Compare Identifier
SORAFENIB
CHEMBL1336
Approved 2005
Properties Compare Identifier
Assay Landscape

Assay Landscape

101
Total Assays
203
Tested Compounds
1
Assay Types
Functional — 101 assays, 203 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 86 203 6.5
organism-based format 13 0 —
assay format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine