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Target Snapshot

CHEMBL4296500 Target Snapshot

THLE-2 · CELL-LINE · Homo sapiens

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238Compounds
26Assays
0Approved Drugs
131.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats THLE-2 as ChEMBL target CHEMBL4296500. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
THLE-2
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296500
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether THLE-2 still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameTHLE-2
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTHLE-2
UniProt AccessionN/A

THLE-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as THLE-2.

Review nameTHLE-2
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5059.0
EC5072.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL252370 8.3 IC50 5.0 Preclinical
CHEMBL4170596 7.96 IC50 11.0 Preclinical
CHEMBL4226772 7.22 IC50 60.0 Preclinical
CHEMBL4787201 6.71 IC50 196.0 Preclinical
CHEMBL4749221 6.64 IC50 231.0 Preclinical
CHEMBL5206613 5.89 IC50 1300.0 Preclinical
CHEMBL4848676 5.85 IC50 1410.0 Preclinical
CHEMBL5175892 5.6 IC50 2500.0 Preclinical
CHEMBL5204031 5.55 IC50 2790.0 Preclinical
CHEMBL5174615 5.54 IC50 2900.0 Preclinical
Distribution

pChEMBL Value Distribution

15
5.0
6
5.5
0
6.0
2
6.5
1
7.0
1
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

26
Total Assays
26
Tested Compounds
3
Assay Types
ADME — 13 assays, 19 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 13 19 5.5
Toxicity — 11 assays, 26 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 11 26 5.0
Functional — 2 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 4 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine