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Target Snapshot

CHEMBL4296505 Target Snapshot

Toledo · CELL-LINE · Homo sapiens

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122Compounds
29Assays
1Approved Drugs
98.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Toledo as ChEMBL target CHEMBL4296505. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Toledo
CELL-LINE · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4296505
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Toledo still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameToledo
Target TypeCELL-LINE
OrganismHomo sapiens
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelToledo
UniProt AccessionN/A

Toledo

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Toledo.

Review nameToledo
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC5096.0
EC502.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4462577 8.25 IC50 5.6 Preclinical
CHEMBL3137309 7.96 IC50 11.0 Approved
CHEMBL1090479 7.82 EC50 15.0 Preclinical
CHEMBL1738758 7.38 IC50 42.0 Clinical
CHEMBL4126153 6.52 IC50 300.0 Preclinical
CHEMBL4128426 6.51 IC50 310.0 Preclinical
CHEMBL4126873 6.5 IC50 320.0 Preclinical
CHEMBL4126269 6.47 IC50 340.0 Preclinical
CHEMBL4126531 6.47 IC50 340.0 Preclinical
CHEMBL4126825 6.43 IC50 370.0 Preclinical
Distribution

pChEMBL Value Distribution

9
5.0
13
5.5
47
6.0
3
6.5
1
7.0
2
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VENETOCLAX
CHEMBL3137309
Approved 2016
Properties Compare Identifier
Assay Landscape

Assay Landscape

29
Total Assays
80
Tested Compounds
1
Assay Types
Functional — 29 assays, 80 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 29 80 6.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine