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Target Snapshot

CHEMBL4296515 Target Snapshot

Bone marrow cell · CELL-LINE

Back to Search Search this target Browse approvals Evidence Card
226Compounds
99Assays
1Approved Drugs
144.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Bone marrow cell as ChEMBL target CHEMBL4296515. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Bone marrow cell
CELL-LINE
As of 2026-09-14
ChEMBL target ID
CHEMBL4296515
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Bone marrow cell still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameBone marrow cell
Target TypeCELL-LINE
OrganismNone
ChEMBL ↗

Next Actions

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelBone marrow cell
UniProt AccessionN/A

Bone marrow cell

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Bone marrow cell.

Review nameBone marrow cell
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50131.0
EC5013.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2021484 10.46 EC50 0.035 Preclinical
CHEMBL2021483 10.4 EC50 0.04 Preclinical
CHEMBL472160 10.32 EC50 0.048 Preclinical
CHEMBL514116 9.66 EC50 0.22 Preclinical
CHEMBL459034 9.37 EC50 0.43 Preclinical
CHEMBL846 8.7 EC50 2.0 Approved
CHEMBL4742712 8.22 EC50 6.0 Preclinical
CHEMBL5397585 7.66 IC50 22.0 Preclinical
CHEMBL5431139 7.4 IC50 40.0 Preclinical
CHEMBL475251 6.83 IC50 147.0 Clinical
Distribution

pChEMBL Value Distribution

26
5.0
9
5.5
13
6.0
4
6.5
2
7.0
1
7.5
1
8.0
1
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

CALCITRIOL
CHEMBL846
Approved 1978
Properties Compare Identifier
Assay Landscape

Assay Landscape

99
Total Assays
36
Tested Compounds
3
Assay Types
Functional — 64 assays, 36 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 47 36 6.2
organism-based format 17 0 —
ADME — 23 assays, 16 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 23 16 5.0
Toxicity — 12 assays, 21 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 12 21 5.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine