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Target Snapshot

CHEMBL4296533 Target Snapshot

Mesenteric artery · TISSUE · Rattus norvegicus

21Compounds
35Assays
1Approved Drugs
25.0Activities
Free Research Context

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Broader Open DB context

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Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

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Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mesenteric artery as ChEMBL target CHEMBL4296533. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mesenteric artery
TISSUE · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL4296533
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMesenteric artery
UniProt AccessionN/A

Mesenteric artery

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mesenteric artery.

Review nameMesenteric artery
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5012.0
EC5013.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL122 7.06 IC50 88.0 Approved
CHEMBL4172138 7.04 IC50 92.0 Preclinical
CHEMBL1797511 7.02 IC50 95.0 Preclinical
CHEMBL4168427 6.3 IC50 499.0 Preclinical
CHEMBL529210 5.8 EC50 1580.0 Preclinical
CHEMBL1797512 5.76 IC50 1750.0 Preclinical
CHEMBL4448821 5.67 EC50 2120.0 Preclinical
CHEMBL4542836 5.58 EC50 2660.0 Preclinical
CHEMBL4449892 5.49 EC50 3230.0 Preclinical
CHEMBL4572747 5.42 EC50 3810.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
7
5.5
1
6.0
0
6.5
3
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ROFECOXIB
CHEMBL122
Approved 1999
Assay Landscape

Assay Landscape

35
Total Assays
14
Tested Compounds
1
Assay Types
Functional — 35 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 30 11 5.5
assay format 5 3 6.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine