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Target Snapshot

CHEMBL4296537 Target Snapshot

Spiral organ of cochlea · TISSUE · Mus musculus

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12Compounds
4Assays
0Approved Drugs
9.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Spiral organ of cochlea as ChEMBL target CHEMBL4296537. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Spiral organ of cochlea
TISSUE · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4296537
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Spiral organ of cochlea still has a stable protein naming contract across sources.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameSpiral organ of cochlea
Target TypeTISSUE
OrganismMus musculus
ChEMBL ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSpiral organ of cochlea
UniProt AccessionN/A

Spiral organ of cochlea

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Spiral organ of cochlea.

Review nameSpiral organ of cochlea
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

EC509.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL488436 8.3 EC50 5.0 Preclinical
CHEMBL445813 7.6 EC50 25.0 Clinical
CHEMBL457177 7.55 EC50 28.0 Preclinical
CHEMBL296586 6.82 EC50 150.0 Preclinical
CHEMBL409450 6.24 EC50 570.0 Preclinical
CHEMBL411491 6.0 EC50 1000.0 Preclinical
CHEMBL1094304 5.52 EC50 3000.0 Preclinical
CHEMBL258805 5.22 EC50 6000.0 Preclinical
CHEMBL4162724 4.82 EC50 15000.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
1
5.5
2
6.0
1
6.5
0
7.0
2
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
9
Tested Compounds
1
Assay Types
Functional — 4 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 4 9 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine