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Target Snapshot

CHEMBL4296541 Target Snapshot

Trachea · TISSUE · Cavia porcellus

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132Compounds
35Assays
1Approved Drugs
63.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Trachea as ChEMBL target CHEMBL4296541. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Trachea
TISSUE · Cavia porcellus
As of 2026-09-13
ChEMBL target ID
CHEMBL4296541
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Trachea still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameTrachea
Target TypeTISSUE
OrganismCavia porcellus
ChEMBL ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelTrachea
UniProt AccessionN/A

Trachea

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Trachea.

Review nameTrachea
OrganismCavia porcellus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase II
Assay Mix

Activity Type Distribution

IC5051.0
EC5012.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5555744 10.7 IC50 0.01995 Preclinical
CHEMBL5505816 10.3 IC50 0.05012 Preclinical
CHEMBL5208201 10.1 IC50 0.07943 Preclinical
CHEMBL5184455 10.0 IC50 0.1 Preclinical
CHEMBL5532029 9.9 IC50 0.1259 Preclinical
CHEMBL5558368 9.9 IC50 0.1259 Preclinical
CHEMBL5550055 9.8 IC50 0.1585 Preclinical
CHEMBL5190387 9.7 IC50 0.1995 Preclinical
CHEMBL6067687 9.6 IC50 0.2512 Preclinical
CHEMBL5208957 9.6 IC50 0.2512 Preclinical
Distribution

pChEMBL Value Distribution

23
5.0
1
5.5
0
6.0
0
6.5
2
7.0
2
7.5
0
8.0
3
8.5
6
9.0
8
9.5
pChEMBL
Assay Landscape

Assay Landscape

35
Total Assays
53
Tested Compounds
1
Assay Types
Functional — 35 assays, 53 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 20 53 6.7
assay format 15 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine