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Target Snapshot

CHEMBL4296577 Target Snapshot

Marburgvirus · ORGANISM · Marburgvirus

Back to Search Search this target Browse approvals Evidence Card
170Compounds
29Assays
8Approved Drugs
212.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Marburgvirus as ChEMBL target CHEMBL4296577. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Marburgvirus
ORGANISM · Marburgvirus
As of 2026-09-13
ChEMBL target ID
CHEMBL4296577
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Marburgvirus still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

Jump to Disease Context
Need a meeting-ready explanation of why this target matters?
Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMarburgvirus
Target TypeORGANISM
OrganismMarburgvirus
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMarburgvirus
UniProt AccessionN/A

Marburgvirus

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Marburgvirus.

Review nameMarburgvirus
OrganismMarburgvirus
Clinical Profile

Clinical Phase Distribution

8
Approved
6
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50103.0
EC50109.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4297643 8.0 EC50 10.0 Clinical
CHEMBL4297643 8.0 IC50 10.0 Clinical
CHEMBL5205032 7.85 EC50 14.0 Preclinical
CHEMBL4874341 7.0 EC50 100.0 Preclinical
CHEMBL1650595 6.52 EC50 300.0 Preclinical
CHEMBL4761341 6.44 IC50 360.0 Preclinical
CHEMBL4647732 6.28 EC50 520.0 Preclinical
CHEMBL4853962 6.28 EC50 520.0 Preclinical
CHEMBL4754810 6.27 IC50 540.0 Preclinical
CHEMBL4797649 6.22 IC50 600.0 Preclinical
Distribution

pChEMBL Value Distribution

54
5.0
37
5.5
18
6.0
2
6.5
1
7.0
1
7.5
2
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

TOREMIFENE
CHEMBL1655
Approved 1996
Properties Compare Identifier
Assay Landscape

Assay Landscape

29
Total Assays
152
Tested Compounds
1
Assay Types
Functional — 29 assays, 152 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 29 152 5.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine