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Target Snapshot

CHEMBL4296578 Target Snapshot

Middle East respiratory syndrome-related coronavirus · ORGANISM · Middle East respiratory syndrome-related coronavirus

Back to Search Search this target Browse approvals Evidence Card
206Compounds
89Assays
18Approved Drugs
245.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Middle East respiratory syndrome-related coronavirus as ChEMBL target CHEMBL4296578. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Middle East respiratory syndrome-related coronavirus
ORGANISM · Middle East respiratory syndrome-related coronavirus
As of 2026-09-13
ChEMBL target ID
CHEMBL4296578
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Middle East respiratory syndrome-related coronavirus still has a stable protein naming contract across sources.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameMiddle East respiratory syndrome-related coronavirus
Target TypeORGANISM
OrganismMiddle East respiratory syndrome-related coronavirus
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMiddle East respiratory syndrome-related coronavirus
UniProt AccessionN/A

Middle East respiratory syndrome-related coronavirus

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Middle East respiratory syndrome-related coronavirus.

Review nameMiddle East respiratory syndrome-related coronavirus
OrganismMiddle East respiratory syndrome-related coronavirus
Clinical Profile

Clinical Phase Distribution

18
Approved
5
Phase III
6
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50118.0
EC50127.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4441971 9.4 EC50 0.4 Preclinical
CHEMBL555196 8.89 EC50 1.3 Preclinical
CHEMBL4590737 8.34 EC50 4.6 Preclinical
CHEMBL5179778 8.33 EC50 4.72 Preclinical
CHEMBL3780681 8.32 EC50 4.8 Preclinical
CHEMBL590799 8.3 EC50 5.0 Clinical
CHEMBL5198073 8.3 EC50 5.01 Preclinical
CHEMBL3989553 8.23 EC50 5.9 Clinical
CHEMBL4438019 8.15 EC50 7.0 Preclinical
CHEMBL4542462 7.7 EC50 20.0 Preclinical
Distribution

pChEMBL Value Distribution

38
5.0
36
5.5
39
6.0
15
6.5
22
7.0
8
7.5
7
8.0
2
8.5
1
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

NIRMATRELVIR
CHEMBL4802135
Approved 2023
Properties Compare Identifier
REMDESIVIR
CHEMBL4065616
Approved 2020
Properties Compare Identifier
GILTERITINIB
CHEMBL3301622
Approved 2018
Properties Compare Identifier
Assay Landscape

Assay Landscape

89
Total Assays
142
Tested Compounds
1
Assay Types
Functional — 89 assays, 142 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 89 142 6.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine