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Target Snapshot

CHEMBL4296612 Target Snapshot

Zika virus · ORGANISM · Zika virus

Back to Search Search this target Browse approvals Evidence Card
1,235Compounds
394Assays
16Approved Drugs
1,294.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Zika virus as ChEMBL target CHEMBL4296612. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Zika virus
ORGANISM · Zika virus
As of 2026-09-14
ChEMBL target ID
CHEMBL4296612
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Zika virus still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameZika virus
Target TypeORGANISM
OrganismZika virus
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelZika virus
UniProt AccessionN/A

Zika virus

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Zika virus.

Review nameZika virus
OrganismZika virus
Clinical Profile

Clinical Phase Distribution

16
Approved
5
Phase III
6
Phase II
2
Phase I
Assay Mix

Activity Type Distribution

IC50308.0
EC50986.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4475511 10.07 IC50 0.0851 Preclinical
CHEMBL4555491 10.01 IC50 0.0977 Preclinical
CHEMBL4557508 10.01 IC50 0.0977 Preclinical
CHEMBL4469100 10.0 IC50 0.1002 Preclinical
CHEMBL4591065 9.96 IC50 0.1109 Preclinical
CHEMBL4465951 9.95 IC50 0.1135 Preclinical
CHEMBL4460915 9.84 IC50 0.1435 Preclinical
CHEMBL4435841 9.83 IC50 0.1466 Preclinical
CHEMBL4455297 9.83 IC50 0.1491 Preclinical
CHEMBL4514485 9.81 IC50 0.1563 Preclinical
Distribution

pChEMBL Value Distribution

210
5.0
164
5.5
105
6.0
31
6.5
16
7.0
8
7.5
2
8.0
1
8.5
9
9.0
11
9.5
pChEMBL
Approved Drugs

Approved Drugs

REMDESIVIR
CHEMBL4065616
Approved 2020
Properties Compare Identifier
SUNITINIB
CHEMBL535
Approved 2006
Properties Compare Identifier
MYCOPHENOLIC ACID
CHEMBL866
Approved 2004
Properties Compare Identifier
TEMOPORFIN
CHEMBL500576
Approved 2001
Properties Compare Identifier
GEMCITABINE
CHEMBL888
Approved 1996
Properties Compare Identifier
CHLOROQUINE
CHEMBL76
Approved 1949
Properties Compare Identifier
Assay Landscape

Assay Landscape

394
Total Assays
547
Tested Compounds
1
Assay Types
Functional — 394 assays, 547 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 386 532 5.6
assay format 8 15 5.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine