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Target Snapshot

CHEMBL4299 Target Snapshot

Subtilisin Carlsberg · SINGLE PROTEIN · Bacillus licheniformis

20Compounds
5Assays
0Approved Drugs
13.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P00780. Use UniProt P00780 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00780 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Subtilisin Carlsberg as ChEMBL target CHEMBL4299, mapped to UniProt P00780. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Subtilisin Carlsberg
SINGLE PROTEIN · Bacillus licheniformis
As of 2026-09-14
ChEMBL target ID
CHEMBL4299
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P00780
Subtilisin Carlsberg
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Subtilisin Carlsberg is the right protein anchor across sources, using UniProt P00780 as the stable mapping.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSubtilisin Carlsberg
UniProt AccessionP00780
Component TypeProtein
Sequence Length379 aa

Subtilisin Carlsberg

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Subtilisin Carlsberg, mapped to UniProt P00780. Sequence length is 379 aa.

Mapped IDP00780
Review nameSubtilisin Carlsberg
OrganismBacillus licheniformis
Assay Mix

Activity Type Distribution

IC501.0
KI12.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL20945 5.1 Ki 8000.0 Preclinical
CHEMBL20726 5.0 Ki 10000.0 Preclinical
CHEMBL21447 4.72 Ki 19000.0 Preclinical
CHEMBL20866 4.64 Ki 23000.0 Preclinical
CHEMBL20421 4.43 Ki 37000.0 Preclinical
CHEMBL79870 4.24 Ki 58000.0 Preclinical
CHEMBL20852 4.12 Ki 75000.0 Preclinical
CHEMBL4216644 4.03 IC50 93000.0 Preclinical
CHEMBL21485 4.0 Ki 100000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

5
Total Assays
12
Tested Compounds
1
Assay Types
Binding — 5 assays, 12 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 12 4.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine