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Target Snapshot

CHEMBL4300 Target Snapshot

Protein S100-B · SINGLE PROTEIN · Homo sapiens

22Compounds
5Assays
1Approved Drugs
20.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P04271. Use UniProt P04271 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P04271 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein S100-B as ChEMBL target CHEMBL4300, mapped to UniProt P04271. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein S100-B
SINGLE PROTEIN · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL4300
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P04271
Protein S100-B
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein S100-B is the right protein anchor across sources, using UniProt P04271 as the stable mapping.

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Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein S100-B
UniProt AccessionP04271
Component TypeProtein
Sequence Length92 aa

Protein S100-B

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Protein S100-B, mapped to UniProt P04271. Sequence length is 92 aa.

Mapped IDP04271
Review nameProtein S100-B
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC508.0
KI5.0
KD7.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL55 6.0 Kd 1000.0 Approved
CHEMBL1478187 5.7 IC50 2000.0 Preclinical
CHEMBL185802 5.7 Kd 2000.0 Preclinical
CHEMBL2335383 5.44 Ki 3600.0 Preclinical
CHEMBL434915 5.35 Kd 4500.0 Preclinical
CHEMBL364410 5.35 Kd 4500.0 Preclinical
CHEMBL2094307 5.3 Ki 5000.0 Preclinical
CHEMBL2335383 5.17 IC50 6800.0 Preclinical
CHEMBL365434 5.09 Kd 8100.0 Preclinical
CHEMBL2094307 5.08 IC50 8400.0 Preclinical
Distribution

pChEMBL Value Distribution

7
5.0
2
5.5
1
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

PENTAMIDINE
CHEMBL55
Approved 1984
Assay Landscape

Assay Landscape

5
Total Assays
14
Tested Compounds
1
Assay Types
Binding — 5 assays, 14 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 5 14 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine