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Target Snapshot

CHEMBL4304 Target Snapshot

Calcium-activated potassium channel subunit alpha-1 · SINGLE PROTEIN · Homo sapiens

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358Compounds
61Assays
1Approved Drugs
103.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q12791. Use UniProt Q12791 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q12791 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Calcium-activated potassium channel subunit alpha-1 as ChEMBL target CHEMBL4304, mapped to UniProt Q12791. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Calcium-activated potassium channel subunit alpha-1
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4304
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q12791
Calcium-activated potassium channel subunit alpha-1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Calcium-activated potassium channel subunit alpha-1 is the right protein anchor across sources, using UniProt Q12791 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred NameCalcium-activated potassium channel subunit alpha-1
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ12791
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCalcium-activated potassium channel subunit alpha-1
UniProt AccessionQ12791
Component TypeProtein
Sequence Length1236 aa

Calcium-activated potassium channel subunit alpha-1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Calcium-activated potassium channel subunit alpha-1, mapped to UniProt Q12791. Sequence length is 1236 aa.

Mapped IDQ12791
Review nameCalcium-activated potassium channel subunit alpha-1
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC5074.0
EC5029.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL445346 8.49 IC50 3.236 Preclinical
CHEMBL448335 7.56 IC50 27.54 Preclinical
CHEMBL465922 7.56 IC50 27.54 Preclinical
CHEMBL524902 6.87 IC50 134.9 Preclinical
CHEMBL504160 6.84 IC50 144.54 Preclinical
CHEMBL511200 6.75 IC50 177.83 Preclinical
CHEMBL506373 6.72 IC50 190.55 Preclinical
CHEMBL464057 6.6 IC50 251.19 Preclinical
CHEMBL190461 6.55 IC50 280.0 Approved
CHEMBL517012 6.55 IC50 281.84 Preclinical
Distribution

pChEMBL Value Distribution

20
5.0
10
5.5
5
6.0
7
6.5
0
7.0
2
7.5
1
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CANNABIDIOL
CHEMBL190461
Approved 2018
Properties Compare Identifier
Assay Landscape

Assay Landscape

61
Total Assays
84
Tested Compounds
3
Assay Types
Binding — 58 assays, 84 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 53 13 5.3
single protein format 5 71 5.3
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —
cell-based format 1 0 —
Toxicity — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine