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Target Snapshot

CHEMBL4312 Target Snapshot

Serine/threonine-protein kinase 36 · SINGLE PROTEIN · Homo sapiens

265Compounds
76Assays
8Approved Drugs
144.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9NRP7. Use UniProt Q9NRP7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9NRP7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Serine/threonine-protein kinase 36 as ChEMBL target CHEMBL4312, mapped to UniProt Q9NRP7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Serine/threonine-protein kinase 36
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL4312
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9NRP7
Serine/threonine-protein kinase 36
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Serine/threonine-protein kinase 36 is the right protein anchor across sources, using UniProt Q9NRP7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelSerine/threonine-protein kinase 36
UniProt AccessionQ9NRP7
Component TypeProtein
Sequence Length1315 aa

Serine/threonine-protein kinase 36

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Serine/threonine-protein kinase 36, mapped to UniProt Q9NRP7. Sequence length is 1315 aa.

Mapped IDQ9NRP7
Review nameSerine/threonine-protein kinase 36
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

8
Approved
2
Phase III
5
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC502.0
KD142.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL1230609 6.75 Kd 180.0 Clinical
CHEMBL5416410 6.68 Kd 210.0 Approved
CHEMBL475251 6.64 Kd 230.0 Clinical
CHEMBL296468 6.58 Kd 260.0 Preclinical
CHEMBL386051 6.54 Kd 290.0 Preclinical
CHEMBL1230122 6.48 Kd 330.0 Preclinical
CHEMBL477772 6.33 Kd 470.0 Approved
CHEMBL288441 6.24 Kd 570.0 Approved
CHEMBL278041 6.1 Kd 790.0 Preclinical
CHEMBL10 6.07 Kd 860.0 Preclinical
Distribution

pChEMBL Value Distribution

19
5.0
11
5.5
7
6.0
7
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

FEDRATINIB
CHEMBL1287853
Approved 2019
BOSUTINIB
CHEMBL288441
Approved 2012
PAZOPANIB
CHEMBL477772
Approved 2009
DASATINIB
CHEMBL5416410
Approved 2006
Assay Landscape

Assay Landscape

76
Total Assays
27
Tested Compounds
1
Assay Types
Binding — 76 assays, 27 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 58 26 5.8
assay format 17 1 5.6
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine