Imipenem-hydrolyzing beta-lactamase · SINGLE PROTEIN · Enterobacter cloacae
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As of 2026-09-14Protein identity stays anchored to UniProt P52663. Use UniProt P52663 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P52663 as the stable identity anchor, then attach disease evidence before program review.
Imipenem-hydrolyzing beta-lactamase
Review this target as Imipenem-hydrolyzing beta-lactamase, mapped to UniProt P52663. Sequence length is 292 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Imipenem-hydrolyzing beta-lactamase as ChEMBL target CHEMBL4314, mapped to UniProt P52663. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Imipenem-hydrolyzing beta-lactamase |
| Target Type | SINGLE PROTEIN |
| Organism | Enterobacter cloacae |
| UniProt | P52663 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Imipenem-hydrolyzing beta-lactamase |
| UniProt Accession | P52663 |
| Component Type | Protein |
| Sequence Length | 292 aa |
Imipenem-hydrolyzing beta-lactamase
Review this target as Imipenem-hydrolyzing beta-lactamase, mapped to UniProt P52663. Sequence length is 292 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL212163 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL380061 | 8.05 | IC50 | 9.0 | Preclinical |
| CHEMBL212760 | 7.75 | IC50 | 18.0 | Preclinical |
| CHEMBL377382 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL212478 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL378041 | 7.57 | IC50 | 27.0 | Preclinical |
| CHEMBL379440 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL211143 | 7.4 | IC50 | 40.0 | Preclinical |
| CHEMBL378119 | 7.25 | IC50 | 56.0 | Preclinical |
| CHEMBL385593 | 7.05 | IC50 | 90.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 13 | 7.3 |