Hemoglobin subunit beta · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Hemoglobin subunit beta shows approved-linked disease relevance led by sickle cell anemia. 2 more disease programs remain visible in the same review block. 2 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P68871. Start with sickle cell anemia, then reuse UniProt P68871 as the stable protein anchor across project notes and exports.
Start with sickle cell anemia, then reuse UniProt P68871 as the stable protein anchor across project notes and exports.
Hemoglobin subunit beta shows approved-linked disease relevance led by sickle cell anemia. 2 more disease programs remain visible in the same review block. 2 linked drugs remain visible in the same block.
Start review with sickle cell anemia because it currently carries approved-linked support. Linked drugs include BETIBEGLOGENE AUTOTEMCEL, LOVOTIBEGLOGENE AUTOTEMCEL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyHemoglobin subunit beta
Review this target as Hemoglobin subunit beta, mapped to UniProt P68871. Sequence length is 147 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hemoglobin subunit beta as ChEMBL target CHEMBL4331, mapped to UniProt P68871. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Hemoglobin subunit beta is the right protein anchor across sources, using UniProt P68871 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why sickle cell anemia is currently framed as approved-linked support. It currently carries 2 linked drugs in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Hemoglobin subunit beta |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P68871 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hemoglobin subunit beta |
| UniProt Accession | P68871 |
| Component Type | Protein |
| Sequence Length | 147 aa |
Hemoglobin subunit beta
Review this target as Hemoglobin subunit beta, mapped to UniProt P68871. Sequence length is 147 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Hemoglobin subunit beta shows approved-linked disease relevance led by sickle cell anemia. 2 more disease programs remain visible in the same review block.
Start review with sickle cell anemia because it currently carries approved-linked support. Linked drugs include BETIBEGLOGENE AUTOTEMCEL, LOVOTIBEGLOGENE AUTOTEMCEL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1232461 | 7.8 | IC50 | 16.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 7 | 1 | 7.8 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 5 | 0 | — |