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Target Snapshot

CHEMBL4335 Target Snapshot

Mitogen-activated protein kinase 11 · SINGLE PROTEIN · Mus musculus

37Compounds
4Assays
0Approved Drugs
34.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9WUI1. Use UniProt Q9WUI1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9WUI1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Mitogen-activated protein kinase 11 as ChEMBL target CHEMBL4335, mapped to UniProt Q9WUI1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Mitogen-activated protein kinase 11
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL4335
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9WUI1
Mitogen-activated protein kinase 11
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Mitogen-activated protein kinase 11 is the right protein anchor across sources, using UniProt Q9WUI1 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelMitogen-activated protein kinase 11
UniProt AccessionQ9WUI1
Component TypeProtein
Sequence Length364 aa

Mitogen-activated protein kinase 11

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Mitogen-activated protein kinase 11, mapped to UniProt Q9WUI1. Sequence length is 364 aa.

Mapped IDQ9WUI1
Review nameMitogen-activated protein kinase 11
OrganismMus musculus
Assay Mix

Activity Type Distribution

IC5034.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2088578 8.11 IC50 7.7 Preclinical
CHEMBL2088591 8.07 IC50 8.5 Preclinical
CHEMBL1098524 8.04 IC50 9.2 Preclinical
CHEMBL2088588 8.03 IC50 9.3 Preclinical
CHEMBL1096192 7.8 IC50 15.8 Preclinical
CHEMBL1098546 7.77 IC50 17.0 Preclinical
CHEMBL2088582 7.57 IC50 27.0 Preclinical
CHEMBL118651 7.55 IC50 28.0 Preclinical
CHEMBL2088575 7.44 IC50 36.0 Preclinical
CHEMBL325706 7.36 IC50 44.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
2
5.5
4
6.0
10
6.5
10
7.0
4
7.5
4
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
34
Tested Compounds
1
Assay Types
Binding — 4 assays, 34 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 4 34 7.0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine