Group 10 secretory phospholipase A2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Group 10 secretory phospholipase A2 shows late clinical disease relevance led by acute coronary syndrome. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt O15496. Start with acute coronary syndrome, then reuse UniProt O15496 as the stable protein anchor across project notes and exports.
Start with acute coronary syndrome, then reuse UniProt O15496 as the stable protein anchor across project notes and exports.
Group 10 secretory phospholipase A2 shows late clinical disease relevance led by acute coronary syndrome. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with acute coronary syndrome because it currently carries late clinical support. Linked drugs include VARESPLADIB METHYL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyGroup 10 secretory phospholipase A2
Review this target as Group 10 secretory phospholipase A2, mapped to UniProt O15496. Sequence length is 165 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Group 10 secretory phospholipase A2 as ChEMBL target CHEMBL4342, mapped to UniProt O15496. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Group 10 secretory phospholipase A2 is the right protein anchor across sources, using UniProt O15496 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why acute coronary syndrome is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Group 10 secretory phospholipase A2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15496 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Group 10 secretory phospholipase A2 |
| UniProt Accession | O15496 |
| Component Type | Protein |
| Sequence Length | 165 aa |
Group 10 secretory phospholipase A2
Review this target as Group 10 secretory phospholipase A2, mapped to UniProt O15496. Sequence length is 165 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Group 10 secretory phospholipase A2 shows late clinical disease relevance led by acute coronary syndrome. 2 more disease programs remain visible in the same review block.
Start review with acute coronary syndrome because it currently carries late clinical support. Linked drugs include VARESPLADIB METHYL. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL477548 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL514705 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL514656 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL4215835 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL474874 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL4210991 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL514692 | 7.82 | IC50 | 15.0 | Preclinical |
| CHEMBL515637 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL148649 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL4171084 | 7.58 | IC50 | 26.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 19 | 85 | 6.3 |
| assay format | 4 | 34 | 6.0 |
| cell-based format | 1 | 1 | 4.6 |